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Compound reference

Melanotan II: CAS number, formula, molecular weight and sequence

Melanotan II (MT-II) is a cyclic heptapeptide melanocortin receptor agonist (lactam-bridged alpha-MSH analogue), CAS 121062-08-6, molecular formula C50H69N15O9, average molecular weight 1024.2 g/mol.

For Laboratory Research Use Only. Not For Human Consumption.

Chemical data

Name
Melanotan II
Synonyms
MT-II · Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
CAS number
121062-08-6
Molecular formula
C50H69N15O9
Average molecular weight
1024.2 g/mol
Monoisotopic mass
1023.5403 Da
Residues
7
Class
Cyclic heptapeptide melanocortin receptor agonist (lactam-bridged alpha-MSH analogue)
PubChem CID
92432
Form supplied
Lyophilized powder
Purity specification
≥98% (HPLC)
Storage
Store lyophilized at -20°C; protect from light

Sequence

XDHfRWK

One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2: N-acetyl-norleucine (X1); Asp2 side chain-Lys7 side chain lactam; D-Phe4; C-terminal Lys7 amide.

Melanotan II molarity calculator

Pre-filled with the average molecular weight above. Change it if your lot is a salt form.

g/mol
mg
mL

Uses the formula weight you enter. For salt forms (acetate, TFA) use the salt's weight, and correct for net peptide content from the lot's certificate where it is reported.

Result

2.441 mM

2.5 mg/mL

References

Publications characterising this compound. Neupeptides makes no representation as to the findings, methods or applicability of the work below. The list is bibliographic and is not a claim about any product.

  1. Al-Obeidi F, et al. NMR and quenched molecular dynamics studies of superpotent linear and cyclic alpha-melanotropins. J Pept Res. 1998. PMID 9650716 · doi:10.1111/j.1399-3011.1998.tb00640.x
  2. Doedens L, et al. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. J Am Chem Soc. 2010. PMID 20496895 · doi:10.1021/ja101428m
  3. Tomassi S, et al. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. J Med Chem. 2022. PMID 35188390 · doi:10.1021/acs.jmedchem.1c01848

Questions

Melanotan II FAQ

The CAS registry number of Melanotan II is 121062-08-6.

Melanotan II has an average molecular weight of 1024.2 g/mol and a monoisotopic mass of 1023.5403 Da, molecular formula C50H69N15O9. Salt forms such as acetate weigh more; the Certificate of Analysis states the form of each lot.

Melanotan II has 7 residues: XDHfRWK. One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2: N-acetyl-norleucine (X1); Asp2 side chain-Lys7 side chain lactam; D-Phe4; C-terminal Lys7 amide.

Neupeptides supplies Melanotan II as a lyophilized powder in a sealed vial, for laboratory research use only. Storage: Store lyophilized at -20°C; protect from light. Each lot has a Certificate of Analysis, linked from the QR code on the box.