Compound reference
Retatrutide: CAS number, formula, molecular weight and sequence
Retatrutide (LY3437943) is a GIP/GLP-1/glucagon receptor tri-agonist peptide (lipidated, 39 residues), CAS 2381089-83-2, molecular formula C221H342N46O68, average molecular weight 4731 g/mol.
For Laboratory Research Use Only. Not For Human Consumption.
Chemical data
- Name
- Retatrutide
- Synonyms
- LY3437943 · LY-3437943
- CAS number
- 2381089-83-2
- Molecular formula
- C221H342N46O68
- Average molecular weight
- 4731 g/mol
- Monoisotopic mass
- 4728.4718 Da
- Residues
- 39
- Class
- GIP/GLP-1/glucagon receptor tri-agonist peptide (lipidated, 39 residues)
- PubChem CID
- 171390338
- Form supplied
- Lyophilized powder
- Purity specification
- ≥98% (HPLC)
- Storage
- Store lyophilized at -20°C; protect from light
Sequence
YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS
One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib (2-aminoisobutyric acid); X13 = alpha-methyl-L-leucine; X20 = Aib; Lys17 epsilon-amine acylated via a [2-(2-aminoethoxy)ethoxy]acetyl (AEEA) - gamma-Glu linker with a C20 icosanedioic (eicosanedioic) acid; C-terminal Ser39 amide.
Retatrutide molarity calculator
Pre-filled with the average molecular weight above. Change it if your lot is a salt form.
Uses the formula weight you enter. For salt forms (acetate, TFA) use the salt's weight, and correct for net peptide content from the lot's certificate where it is reported.
Result
528.43 µM
2.5 mg/mL
References
Publications characterising this compound. Neupeptides makes no representation as to the findings, methods or applicability of the work below. The list is bibliographic and is not a claim about any product.
- Li W, et al. Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov. 2024. PMID 39019866 · doi:10.1038/s41421-024-00700-0
Questions
Retatrutide FAQ
The CAS registry number of Retatrutide is 2381089-83-2.
Retatrutide has an average molecular weight of 4731 g/mol and a monoisotopic mass of 4728.4718 Da, molecular formula C221H342N46O68. Salt forms such as acetate weigh more; the Certificate of Analysis states the form of each lot.
Retatrutide has 39 residues: YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS. One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib (2-aminoisobutyric acid); X13 = alpha-methyl-L-leucine; X20 = Aib; Lys17 epsilon-amine acylated via a [2-(2-aminoethoxy)ethoxy]acetyl (AEEA) - gamma-Glu linker with a C20 icosanedioic (eicosanedioic) acid; C-terminal Ser39 amide.
Neupeptides supplies Retatrutide as a lyophilized powder in a sealed vial, for laboratory research use only. Storage: Store lyophilized at -20°C; protect from light. Each lot has a Certificate of Analysis, linked from the QR code on the box.