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Compound reference

Tirzepatide: CAS number, formula, molecular weight and sequence

Tirzepatide (LY3298176) is a GIP/GLP-1 receptor dual agonist peptide (lipidated, 39 residues), CAS 2023788-19-2, molecular formula C225H348N48O68, average molecular weight 4813 g/mol.

For Laboratory Research Use Only. Not For Human Consumption.

Chemical data

Name
Tirzepatide
Synonyms
LY3298176
CAS number
2023788-19-2
Molecular formula
C225H348N48O68
Average molecular weight
4813 g/mol
Monoisotopic mass
4810.5249 Da
Residues
39
Class
GIP/GLP-1 receptor dual agonist peptide (lipidated, 39 residues)
PubChem CID
156588324
Form supplied
Lyophilized powder
Purity specification
≥98% (HPLC)
Storage
Store lyophilized at -20°C; protect from light

Sequence

YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS

One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib; X13 = Aib; Lys20 epsilon-amine acylated via gamma-Glu-2x[2-(2-aminoethoxy)ethoxy]acetyl (2xAEEA) linker with a C20 icosanedioic acid; C-terminal Ser39 amide.

Tirzepatide molarity calculator

Pre-filled with the average molecular weight above. Change it if your lot is a salt form.

g/mol
mg
mL

Uses the formula weight you enter. For salt forms (acetate, TFA) use the salt's weight, and correct for net peptide content from the lot's certificate where it is reported.

Result

519.427 µM

2.5 mg/mL

References

Publications characterising this compound. Neupeptides makes no representation as to the findings, methods or applicability of the work below. The list is bibliographic and is not a claim about any product.

  1. Willard FS, et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight. 2020. PMID 32730231 · doi:10.1172/jci.insight.140532
  2. Sun B, et al. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022. PMID 35333651 · doi:10.1073/pnas.2116506119
  3. Zhao F, et al. Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun. 2022. PMID 35217653 · doi:10.1038/s41467-022-28683-0

Questions

Tirzepatide FAQ

The CAS registry number of Tirzepatide is 2023788-19-2.

Tirzepatide has an average molecular weight of 4813 g/mol and a monoisotopic mass of 4810.5249 Da, molecular formula C225H348N48O68. Salt forms such as acetate weigh more; the Certificate of Analysis states the form of each lot.

Tirzepatide has 39 residues: YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS. One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib; X13 = Aib; Lys20 epsilon-amine acylated via gamma-Glu-2x[2-(2-aminoethoxy)ethoxy]acetyl (2xAEEA) linker with a C20 icosanedioic acid; C-terminal Ser39 amide.

Neupeptides supplies Tirzepatide as a lyophilized powder in a sealed vial, for laboratory research use only. Storage: Store lyophilized at -20°C; protect from light. Each lot has a Certificate of Analysis, linked from the QR code on the box.