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Compound reference

Semaglutide: CAS number, formula, molecular weight and sequence

Semaglutide (NN9535) is a GLP-1 receptor agonist peptide (acylated GLP-1 analogue, 31 residues), CAS 910463-68-2, molecular formula C187H291N45O59, average molecular weight 4114 g/mol.

For Laboratory Research Use Only. Not For Human Consumption.

Chemical data

Name
Semaglutide
Synonyms
NN9535 · NNC 0113-0217
CAS number
910463-68-2
Molecular formula
C187H291N45O59
Average molecular weight
4114 g/mol
Monoisotopic mass
4111.1154 Da
Residues
31
Class
GLP-1 receptor agonist peptide (acylated GLP-1 analogue, 31 residues)
PubChem CID
56843331
Form supplied
Lyophilized powder
Purity specification
≥98% (HPLC)
Storage
Store lyophilized at -20°C; protect from light

Sequence

HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG

One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib; Lys20 N6-acylated with 17-carboxyheptadecanoyl (C18 diacid)-gamma-Glu-2x[2-(2-aminoethoxy)ethoxy]acetyl; C-terminal Gly free acid.

Semaglutide molarity calculator

Pre-filled with the average molecular weight above. Change it if your lot is a salt form.

g/mol
mg
mL

Uses the formula weight you enter. For salt forms (acetate, TFA) use the salt's weight, and correct for net peptide content from the lot's certificate where it is reported.

Result

607.681 µM

2.5 mg/mL

References

Publications characterising this compound. Neupeptides makes no representation as to the findings, methods or applicability of the work below. The list is bibliographic and is not a claim about any product.

  1. Lau J, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015. PMID 26308095 · doi:10.1021/acs.jmedchem.5b00726
  2. Zhang X, et al. Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep. 2021. PMID 34260945 · doi:10.1016/j.celrep.2021.109374

Questions

Semaglutide FAQ

The CAS registry number of Semaglutide is 910463-68-2.

Semaglutide has an average molecular weight of 4114 g/mol and a monoisotopic mass of 4111.1154 Da, molecular formula C187H291N45O59. Salt forms such as acetate weigh more; the Certificate of Analysis states the form of each lot.

Semaglutide has 31 residues: HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG. One-letter convention here: X = non-proteinogenic residue, lowercase = D-amino acid. X2 = Aib; Lys20 N6-acylated with 17-carboxyheptadecanoyl (C18 diacid)-gamma-Glu-2x[2-(2-aminoethoxy)ethoxy]acetyl; C-terminal Gly free acid.

Neupeptides supplies Semaglutide as a lyophilized powder in a sealed vial, for laboratory research use only. Storage: Store lyophilized at -20°C; protect from light. Each lot has a Certificate of Analysis, linked from the QR code on the box.